2019

  • Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons.
    Raina A, Mahajani S, Bähr M, Kügler S.
    Mol Neurobiol. 2019 Jul 17. doi: 10.1007/s12035-019-01701-x. [Epub ahead of print]PMID: 31317490
    PubMed

  • Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O 2 Consumption and ROS Release.
    Can K, Menzfeld C, Rinne L, Rehling P, Kügler S, Golubiani G, Dudek J, Müller M.
    Front Physiol. 2019 Apr 30;10:479. doi: 10.3389/fphys.2019.00479. eCollection 2019.PMID: 31114506
    PubMed

  • β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.
    Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A.
    Nature. 2019 Feb;566(7745):503-508. doi: 10.1038/s41586-019-0964-2. Epub 2019 Feb 20. Erratum in: Nature. 2019 Mar;567(7749):E15.
    PubMed

  • MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain.
    Noroozian Z, Xhima K, Huang Y, Kaspar BK, Kügler S, Hynynen K, Aubert I.
    Methods Mol Biol. 2019;1950:177-197. doi: 10.1007/978-1-4939-9139-6_10.PMID: 30783974
    PubMed

  • CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies.
    Castro-Sánchez S, García-Yagüe ÁJ, Kügler S, Lastres-Becker I.
    Redox Biol. 2019 Apr;22:101118. doi: 10.1016/j.redox.2019.101118. Epub 2019 Feb 6.PMID: 30769286
    PubMed

  • Probing the function of glycinergic neurons in the mouse respiratory network using optogenetics.
    Fortuna MG, Kügler S, Hülsmann S.
    Respir Physiol Neurobiol. 2019 Jul;265:141-152. doi: 10.1016/j.resp.2018.10.008. Epub 2018 Nov 3.PMID: 30395936
    PubMed

  • Vti1b promotes TRPV1 sensitization during inflammatory pain.
    Sondermann JR, Barry AM, Jahn O, Michel N, Abdelaziz R, Kügler S, Gomez-Varela D, Schmidt M.
    Pain. 2019 Feb;160(2):508-527. doi: 10.1097/j.pain.0000000000001418.PMID: 30335684
    PubMed

  • Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.
    Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.
    Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326. PubMed PMID: 30219847.
    PubMed

2018

  • A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice.
    Al-Moyed H, Cepeda AP, Jung S, Moser T, Kügler S, Reisinger E.
    EMBO Mol Med. 2018 Dec 3. pii: e9396. doi: 10.15252/emmm.201809396. [Epub ahead of print] PubMed PMID: 30509897.
    PubMed

  • Therapeutic efficacy of regulable GDNF expression for Huntington’s and Parkinson’s disease by a high-induction, background-free „GeneSwitch“ vector.
    Cheng S, Tereshchenko J, Zimmer V, Vachey G, Pythoud C, Rey M, Liefhebber J, Raina A, Streit F, Mazur A, Bähr M, Konstantinova P, Déglon N, Kügler S.
    Exp Neurol. 2018 Nov;309:79-90. doi: 10.1016/j.expneurol.2018.07.017. Epub 2018 Aug 1. PubMed PMID: 30076831.
    PubMed

  • Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
    Cuadrado A, Kügler S, Lastres-Becker I.
    Redox Biol. 2018 Apr;14:522-534. doi: 10.1016/j.redox.2017.10.010. Epub 2017 Nov 6. PubMed PMID: 29121589; PubMed Central PMCID: PMC5681345.
    PubMed

  • Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity.
    Tolö J, Taschenberger G, Leite K, Stahlberg MA, Spehlbrink G, Kues J, Munari F, Capaldi S, Becker S, Zweckstetter M, Dean C, Bähr M, Kügler S. Front Mol Neurosci. 2018 Mar 7;11:49. doi: 10.3389/fnmol.2018.00049. eCollection 2018. PubMed PMID: 29563864; PubMed Central PMCID: PMC5845890.
    PubMed

2017

  • A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC1D-Driven Transgene Expression in AAV-Mediated Gene Transfer.
    Taschenberger G, Tereshchenko J, Kügler S.  Mol Ther Nucleic Acids. 2017 Sep 15;8:13-25. doi: 10.1016/j.omtn.2017.03.009. Epub 2017 Apr 6. PubMed PMID: 28918015; PubMed Central PMCID: PMC5476465.
    PubMed

  • Lentiviral Delivery of miR-133b Improves Functional Recovery After Spinal Cord Injury in Mice.
    Theis T, Yoo M, Park CS, Chen J, Kügler S, Gibbs KM, Schachner M.
    Mol Neurobiol. 2017 Aug;54(6):4659-4671. doi: 10.1007/s12035-016-0007-z. Epub 2016 Jul 13. PubMed PMID: 27412702.
    PubMed

  • Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse Brain.
    Zahur M, Tolö J, Bähr M, Kügler S.
    Front Mol Neurosci. 2017 May 23;10:142. doi: 10.3389/fnmol.2017.00142. eCollection 2017. PubMed PMID: 28588449; PubMed Central PMCID: PMC5440507.
    PubMed

  • The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
    de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.
    PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601. PubMed PMID: 28257421; PubMed Central PMCID: PMC5336201.
    PubMed

2016

  • Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
    Drinkut A, Tillack K, Meka DP, Schulz JB, Kügler S, Kramer ER.
    Cell Death Dis. 2016 Sep 8;7(9):e2359. doi: 10.1038/cddis.2016.263. Erratum in: Cell Death Dis. 2018 May 25;9(6):634. PubMed PMID: 27607574; PubMed Central PMCID: PMC5059866.
    PubMed

  • Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson’s Disease.
    Lastres-Becker I, García-Yagüe AJ, Scannevin RH, Casarejos MJ, Kügler S, Rábano A, Cuadrado A.
    Antioxid Redox Signal. 2016 Jul 10;25(2):61-77. doi: 10.1089/ars.2015.6549. Epub 2016 Apr 27. PubMed PMID: 27009601; PubMed Central PMCID: PMC4943471.
    PubMed

  • Thalamocortical Connections Drive Intracortical Activation of Functional Columns in the Mislaminated Reeler Somatosensory Cortex.
    Wagener RJ, Witte M, Guy J, Mingo-Moreno N, Kügler S, Staiger JF.
    Cereb Cortex. 2016 Feb;26(2):820-37. doi: 10.1093/cercor/bhv257. Epub 2015 Nov 11. PubMed PMID: 26564256; PubMed Central PMCID: PMC4712806.
    PubMed

  • Tissue-Specific Promoters in the CNS.
    Kügler S.
    Methods Mol Biol. 2016;1382:81-91. doi: 10.1007/978-1-4939-3271-9_6. PubMed PMID: 26611580.
    PubMed

2015

  • Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload.
    Montes-Cobos E, Li X, Fischer HJ, Sasse A, Kügler S, Didié M, Toischer K, Fassnacht M, Dressel R, Reichardt HM.
    PLoS One. 2015 Nov 25;10(11):e0143954. doi: 10.1371/journal.pone.0143954. eCollection 2015. PubMed PMID: 26605921; PubMed Central PMCID: PMC4659617.
    PubMed

  • Increased GABAergic Efficacy of Central Amygdala Projections to Neuropeptide S Neurons in the Brainstem During Fear Memory Retrieval.
    Jüngling K, Lange MD, Szkudlarek HJ, Lesting J, Erdmann FS, Doengi M, Kügler S, Pape HC.
    Neuropsychopharmacology. 2015 Nov;40(12):2753-63. doi: 10.1038/npp.2015.125. Epub 2015 May 4.
    PubMed

  • Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
    Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T.
    Nat Neurosci. 2015 Nov;18(11):1584-93. doi: 10.1038/nn.4132. Epub 2015 Oct 5. PubMed PMID: 26436904; PubMed Central PMCID: PMC4694577.
    PubMed

  • Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
    Duarte-Neves J, Gonçalves N, Cunha-Santos J, Simões AT, den Dunnen WF, Hirai H, Kügler S, Cavadas C, Pereira de Almeida L.
    Hum Mol Genet. 2015 Oct 1;24(19
    PubMed

  • Dimerization propensities of Synucleins are not predictive for Synuclein aggregation.
    Eckermann K, Kügler S, Bähr M.  Biochim Biophys Acta. 2015 Aug;1852(8):1658-64. doi: 10.1016/j.bbadis.2015.05.002. Epub 2015 May 8. PubMed PMID: 25960149.
    PubMed

  • AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury.
    Challagundla M, Koch JC, Ribas VT, Michel U, Kügler S, Ostendorf T, Bradke F, Müller HW, Bähr M, Lingor P.
    J Neurochem. 2015 Jul;134(2):261-75. doi: 10.1111/jnc.13102. Epub 2015 Apr 13. PubMed PMID: 25807858.
    PubMed

  • Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.
    Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A.
    Acta Neuropathol. 2015 May;129(5):695-713. doi: 10.1007/s00401-015-1408-1. Epub 2015 Mar 17. PubMed PMID: 25778619; PubMed Central PMCID: PMC4405286.
    PubMed

  • Neuropeptide Y stimulates autophagy in hypothalamic neurons.
    Aveleira CA, Botelho M, Carmo-Silva S, Pascoal JF, Ferreira-Marques M, Nóbrega C, Cortes L, Valero J, Sousa-Ferreira L, Álvaro AR, Santana M, Kügler S, Pereira de Almeida L, Cavadas C.
    Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1642-51. doi: 10.1073/pnas.1416609112. Epub 2015 Mar 16. PubMed PMID: 25775546; PubMed Central PMCID: PMC4386327.
    PubMed

  • Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways.
    Erdmann F, Kügler S, Blaesse P, Lange MD, Skryabin BV, Pape HC, Jüngling K. PLoS One. 2015 Feb 25;10(2):e0117319. doi: 10.1371/journal.pone.0117319. eCollection 2015. PubMed PMID: 25714705; PubMed Central PMCID: PMC4340626.
    PubMed

2014

  • Alpha-synuclein mutations impair axonal regeneration in models of Parkinson’s disease.
    Tönges L, Szegö EM, Hause P, Saal KA, Tatenhorst L, Koch JC, D Hedouville Z, Dambeck V, Kügler S, Dohm CP, Bähr M, Lingor P.
    Front Aging Neurosci. 2014 Sep 10;6:239. doi: 10.3389/fnagi.2014.00239. eCollection 2014. PubMed PMID: 25309425; PubMed Central PMCID: PMC4159996.
    PubMed

  • Pre-existing immunity to adeno-associated virus (AAV)2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-hydroxydopamine model of Parkinson’s disease.
    Janelidze S, Nordström U, Kügler S, Brundin P.
    J Gene Med. 2014 Sep-Oct;16(9-10):300-8. doi: 10.1002/jgm.2779. PubMed PMID: 25303717.
    PubMed

  • Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson’s disease.
    Tereshchenko J, Maddalena A, Bähr M, Kügler S.
    Neurobiol Dis. 2014 May;65:35-42. doi: 10.1016/j.nbd.2014.01.009. Epub 2014 Jan 15. PubMed PMID: 24440408.
    PubMed

  • Metabolic differences in hippocampal ‚Rett‘ neurons revealed by ATP imaging.
    Toloe J, Mollajew R, Kügler S, Mironov SL.
    Mol Cell Neurosci. 2014 Mar;59:47-56. doi: 10.1016/j.mcn.2013.12.008. Epub 2014 Jan 3. PubMed PMID: 24394521.
    PubMed

  • Optogenetic stimulation of the auditory pathway.
    Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T.
    J Clin Invest. 2014 Mar;124(3):1114-29. doi: 10.1172/JCI69050. Epub 2014 Feb 10. PubMed PMID: 24509078; PubMed Central PMCID: PMC3934189.
    PubMed

  • Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
    Ziemlińska E, Kügler S, Schachner M, Wewiór I, Czarkowska-Bauch J, Skup M.
    PLoS One. 2014 Feb 14;9(2):e88833. doi: 10.1371/journal.pone.0088833. eCollection 2014. Erratum in: PLoS One. 2014;9(3):e92439. PubMed PMID: 24551172; PubMed Central PMCID: PMC3925164.
    PubMed

  • Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.
    Neef J, Jung S, Wong AB, Reuter K, Pangrsic T, Chakrabarti R, Kügler S, Lenz C, Nouvian R, Boumil RM, Frankel WN, Wichmann C, Moser T.
    J Neurosci. 2014 Jan 15;34(3):705-16. doi: 10.1523/JNEUROSCI.3313-13.2014. PubMed PMID: 24431429; PubMed Central PMCID: PMC3891952.
    PubMed

  • Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.
    Lastres-Becker I, Innamorato NG, Jaworski T, Rábano A, Kügler S, Van Leuven F, Cuadrado A.
    Brain. 2014 Jan;137(Pt 1):78-91. doi: 10.1093/brain/awt323. Epub 2013 Nov 25. PubMed PMID: 24277722.
    PubMed

2013

  • β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.
    Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S. Ann Neurol. 2013 Jul;74(1):109-18. doi: 10.1002/ana.23905. Epub 2013 Aug 6. PubMed PMID: 23536356.
    PubMed

  • Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer’s disease pathology in mice.
    Djogo N, Jakovcevski I, Müller C, Lee HJ, Xu JC, Jakovcevski M, Kügler S, Loers G, Schachner M.
    Neurobiol Dis. 2013 Aug;56:104-15. doi: 10.1016/j.nbd.2013.04.014. Epub 2013 Apr 29. PubMed PMID: 23639788.
    PubMed

  • Adeno-associated Virus-mediated, Mifepristone-regulated Transgene Expression in the Brain.
    Maddalena A, Tereshchenko J, Bähr M, Kügler S.
    Mol Ther Nucleic Acids. 2013 Jul 16;2:e106. doi: 10.1038/mtna.2013.35. PubMed PMID: 23860550; PubMed Central PMCID: PMC3731885.
    PubMed

  • Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.
    Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL.
    Front Mol Neurosci. 2013 Mar 4;6:2. doi: 10.3389/fnmol.2013.00002. eCollection 2013. PubMed PMID: 23459413; PubMed Central PMCID: PMC3586699.
    PubMed

2012

  • Reorganization of cortical population activity imaged throughout long-term sensory deprivation.
    Margolis DJ, Lütcke H, Schulz K, Haiss F, Weber B, Kügler S, Hasan MT, Helmchen F.
    Nat Neurosci. 2012 Nov;15(11):1539-46. doi: 10.1038/nn.3240. Epub 2012 Oct 21. PubMed PMID: 23086335.
    PubMed

  • Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.
    Simões AT, Gonçalves N, Koeppen A, Déglon N, Kügler S, Duarte CB, Pereira de Almeida L.
    Brain. 2012 Aug;135(Pt 8):2428-39. doi: 10.1093/brain/aws177. PubMed PMID: 22843411.
    PubMed

  • Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.
    Taschenberger G, Garrido M, Tereshchenko Y, Bähr M, Zweckstetter M, Kügler S.
    Acta Neuropathol. 2012 May;123(5):671-83. doi: 10.1007/s00401-011-0926-8. Epub 2011 Dec 14. PubMed PMID: 22167382; PubMed Central PMCID: PMC3316935.
    PubMed

  • HDAC1 regulates fear extinction in mice.
    Bahari-Javan S, Maddalena A, Kerimoglu C, Wittnam J, Held T, Bähr M, Burkhardt S, Delalle I, Kügler S, Fischer A, Sananbenesi F.
    J Neurosci. 2012 Apr 11;32(15):5062-73. doi: 10.1523/JNEUROSCI.0079-12.2012. PubMed PMID: 22496552.
    PubMed

  • Efficient gene therapy for Parkinson’s disease using astrocytes as hosts for localized neurotrophic factor delivery.
    Drinkut A, Tereshchenko Y, Schulz JB, Bähr M, Kügler S.
    Mol Ther. 2012 Mar;20(3):534-43. doi: 10.1038/mt.2011.249. Epub 2011 Nov 15. PubMed PMID: 22086235; PubMed Central PMCID: PMC3293619.
    PubMed

  • Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator.
    Minderer M, Liu W, Sumanovski LT, Kügler S, Helmchen F, Margolis DJ.
    J Physiol. 2012 Jan 1;590(1):99-107. doi: 10.1113/jphysiol.2011.219014. Epub 2011 Nov 14. PubMed PMID: 22083602; PubMed Central PMCID: PMC3300049.
    PubMed

2011

  • GSK-3α/β kinases and amyloid production in vivo.
    Jaworski T, Dewachter I, Lechat B, Gees M, Kremer A, Demedts D, Borghgraef P, Devijver H, Kügler S, Patel S, Woodgett JR, Van Leuven F.
    Nature. 2011 Dec 7;480(7376):E4-5; discussion E6. doi: 10.1038/nature10615. PubMed PMID: 22158250.
    PubMed

  • Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration.
    Jaworski T, Lechat B, Demedts D, Gielis L, Devijver H, Borghgraef P, Duimel H, Verheyen F, Kügler S, Van Leuven F.
    Am J Pathol. 2011 Oct;179(4):2001-15. doi: 10.1016/j.ajpath.2011.06.025. Epub 2011 Aug 10. PubMed PMID: 21839061; PubMed Central PMCID: PMC3181369.
    PubMed

  • Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice.
    Peng SP, Kügler S, Ma ZK, Shen YQ, Schachner M.
    Neuroreport. 2011 Aug 24;22(12):565-9. PubMed PMID: 21879483.
    PubMed

  • Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats.
    Sousa-Ferreira L, Garrido M, Nascimento-Ferreira I, Nobrega C, Santos-Carvalho A, Alvaro AR, Rosmaninho-Salgado J, Kaster M, Kügler S, de Almeida LP, Cavadas C.
    PLoS One. 2011;6(7):e22333. doi: 10.1371/journal.pone.0022333. Epub 2011 Jul 22. PubMed PMID: 21799827; PubMed Central PMCID: PMC3142146.
    PubMed

  • Sumoylation inhibits alpha-synuclein aggregation and toxicity.
    Krumova P, Meulmeester E, Garrido M, Tirard M, Hsiao HH, Bossis G, Urlaub H, Zweckstetter M, Kügler S, Melchior F, Bähr M, Weishaupt JH.
    J Cell Biol. 2011 Jul 11;194(1):49-60. doi: 10.1083/jcb.201010117. PubMed PMID: 21746851; PubMed Central PMCID: PMC3135405.
    PubMed

  • A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.
    Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D.
    EMBO J. 2011 Jun 24;30(14):2793-804. doi: 10.1038/emboj.2011.202. PubMed PMID: 21701557; PubMed Central PMCID: PMC3160257.
    PubMed

  • Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.
    Sousa-Ferreira L, Álvaro AR, Aveleira C, Santana M, Brandão I, Kügler S, de Almeida LP, Cavadas C.
    PLoS One. 2011 May 11;6(5):e19745. doi: 10.1371/journal.pone.0019745. PubMed PMID: 21589937; PubMed Central PMCID: PMC3092771.
    PubMed

  • Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome.
    Mironov SL, Skorova EY, Kügler S.
    Neuropharmacology. 2011 May;60(6):869-77. doi: 10.1016/j.neuropharm.2011.01.002. Epub 2011 Jan 11. PubMed PMID: 21232545.
    PubMed

  • Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons.
    Garrido M, Tereshchenko Y, Zhevtsova Z, Taschenberger G, Bähr M, Kügler S.
    Acta Neuropathol. 2011 Apr;121(4):475-85. doi: 10.1007/s00401-010-0791-x. Epub 2010 Dec 30. PubMed PMID: 21191602; PubMed Central PMCID: PMC3058355.
    PubMed

  • Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.
    Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T.
    J Neurosci. 2011 Mar 30;31(13):4886-95. doi: 10.1523/JNEUROSCI.5122-10.2011. PubMed PMID: 21451027; PubMed Central PMCID: PMC3083821.
    PubMed

2010

  • Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.
    Kurimoto T, Yin Y, Omura K, Gilbert HY, Kim D, Cen LP, Moko L, Kügler S, Benowitz LI.
    J Neurosci. 2010 Nov 17;30(46):15654-63. doi: 10.1523/JNEUROSCI.4340-10.2010. PubMed PMID: 21084621; PubMed Central PMCID:PMC3001271.
    PubMed

  • Alzheimer’s disease: old problem, new views from transgenic and viral models.
    Jaworski T, Dewachter I, Seymour CM, Borghgraef P, Devijver H, Kügler S, Van Leuven F.
    Biochim Biophys Acta. 2010 Oct;1802(10):808-18. doi: 10.1016/j.bbadis.2010.03.005. Epub 2010 Mar 21. Review. PubMed PMID:20332023.
    PubMed

  • The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration.
    Chen J, Joon Lee H, Jakovcevski I, Shah R, Bhagat N, Loers G, Liu HY, Meiners S, Taschenberger G, Kügler S, Irintchev A, Schachner M.
    Mol Ther. 2010 Oct;18(10):1769-77. doi: 10.1038/mt.2010.133. Epub 2010 Jul 6. PubMed PMID: 20606643; PubMed Central PMCID:PMC2951554.
    PubMed

  • Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer’s disease.
    Jaworski T, Kügler S, Van Leuven F.
    Int J Alzheimers Dis. 2010 Aug 24;2010. pii: 573138. doi: 10.4061/2010/573138. PubMed PMID: 20862366; PubMed Central PMCID: PMC2938448.
    PubMed

  • Evaluation of long-term upregulation of Calbindin D28K as a preventive approach for ischaemic stroke.
    Freimann FB, Crome O, Shevtsova Z, Bähr M, Kügler S.
    Int J Stroke. 2010 Aug;5(4):319-20. doi: 10.1111/j.1747-4949.2010.00446.x. PubMed PMID: 20636715.
    PubMed

  • CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
    Shevtsova Z, Garrido M, Weishaupt J, Saftig P, Bähr M, Lühder F, Kügler S.
    Am J Pathol. 2010 Jul;177(1):271-9. doi: 10.2353/ajpath.2010.091267. Epub 2010 May 20. PubMed PMID: 20489146; PubMed Central PMCID:PMC2893670.
    PubMed

  • Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice.
    Lütcke H, Murayama M, Hahn T, Margolis DJ, Astori S, Zum Alten Borgloh SM, Göbel W, Yang Y, Tang W, Kügler S, Sprengel R, Nagai T, Miyawaki A, Larkum ME, Helmchen F, Hasan MT.
    Front Neural Circuits. 2010 Apr 29;4:9. doi: 10.3389/fncir.2010.00009. eCollection 2010. PubMed PMID: 20461230; PubMed Central PMCID: PMC2866455.
    PubMed

  • Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.
    Büttner N, Johnsen SA, Kügler S, Vogel T.
    Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7042-7. doi: 10.1073/pnas.0912041107. Epub 2010 Mar 26. PubMed PMID: 20348416; PubMed Central PMCID: PMC2872432.
    PubMed

2009

  • Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson’s disease models.
    Karpinar DP, Balija MB, Kügler S, Opazo F, Rezaei-Ghaleh N, Wender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L, Voigt A, Braus GH, Giller K, Becker S, Herzig A, Baldus M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M.
    EMBO J. 2009 Oct 21;28(20):3256-68. doi: 10.1038/emboj.2009.257. Epub 2009 Sep 10. PubMed PMID: 19745811; PubMed Central PMCID: PMC2771093.
    PubMed

  • AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.
    Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, Borghgraef P, Devijver H, Filipkowski RK, Kaczmarek L, Kügler S, Van Leuven F.
    PLoS One. 2009 Oct 1;4(10):e7280. doi: 10.1371/journal.pone.0007280. PubMed PMID: 19794916; PubMed Central PMCID: PMC2748684.
    PubMed

  • Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering.
    Mironov SL, Skorova E, Hartelt N, Mironova LA, Hasan MT, Kügler S.
    J Physiol. 2009 Jun 1;587(Pt 11):2473-85. doi: 10.1113/jphysiol.2009.169805. Epub 2009 Apr 9. Erratum in: J Physiol. 2011 Aug 1;589(Pt 15):3897. PubMed PMID: 19359374; PubMed Central PMCID: PMC2714014.
    PubMed

  • Imaging cytoplasmic cAMP in mouse brainstem neurons.
    Mironov SL, Skorova E, Taschenberger G, Hartelt N, Nikolaev VO, Lohse MJ, Kügler S.
    BMC Neurosci. 2009 Mar 27;10:29. doi: 10.1186/1471-2202-10-29. PubMed PMID: 19327133; PubMed Central PMCID: PMC2674597.
    PubMed

2008

  • BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.
    Planchamp V, Bermel C, Tönges L, Ostendorf T, Kügler S, Reed JC, Kermer P, Bähr M, Lingor P.
    Brain. 2008 Oct;131(Pt 10):2606-19. doi: 10.1093/brain/awn196. Epub 2008 Aug 29. PubMed PMID: 18757464.
    PubMed

  • Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor.
    Wallace DJ, Meyer zum Alten Borgloh S, Astori S, Yang Y, Bausen M, Kügler S, Palmer AE, Tsien RY, Sprengel R, Kerr JN, Denk W, Hasan MT.
    Nat Methods. 2008 Sep;5(9):797-804. doi: 10.1038/nmeth.1242. PubMed PMID: 19160514.
    PubMed

  • Imaging of respiratory network topology in living brainstem slices.
    Hartelt N, Skorova E, Manzke T, Suhr M, Mironova L, Kügler S, Mironov SL.
    Mol Cell Neurosci. 2008 Mar;37(3):425-31. doi: 10.1016/j.mcn.2007.10.011. Epub 2007 Oct 30. PubMed PMID: 18203620.
    PubMed

2007

  • BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.
    Planchamp V, Bermel C, Tönges L, Ostendorf T, Kügler S, Reed JC, Kermer P, Bähr M, Lingor P.
    Brain. 2008 Oct;131(Pt 10):2606-19. doi: 10.1093/brain/awn196. Epub 2008 Aug 29. PubMed PMID: 18757464.
    PubMed

  • Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor.
    Wallace DJ, Meyer zum Alten Borgloh S, Astori S, Yang Y, Bausen M, Kügler S, Palmer AE, Tsien RY, Sprengel R, Kerr JN, Denk W, Hasan MT.
    Nat Methods. 2008 Sep;5(9):797-804. doi: 10.1038/nmeth.1242. PubMed PMID: 19160514.
    PubMed

  • Imaging of respiratory network topology in living brainstem slices.
    Hartelt N, Skorova E, Manzke T, Suhr M, Mironova L, Kügler S, Mironov SL.
    Mol Cell Neurosci. 2008 Mar;37(3):425-31. doi: 10.1016/j.mcn.2007.10.011. Epub 2007 Oct 30. PubMed PMID: 18203620.
    PubMed

2006

  • Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons.
    Shevtsova Z, Malik I, Garrido M, Schöll U, Bähr M, Kügler S.
    Gene Ther. 2006 Nov;13(22):1569-78. Epub 2006 Jul 13. PubMed PMID: 16838029.
    PubMed

  • Improved high-capacity adenoviral vectors for high-level neuron-restricted gene transfer to the CNS.
    Hermening S, Kügler S, Bähr M, Isenmann S.
    J Virol Methods. 2006 Sep;136(1-2):30-7. Epub 2006 May 2. PubMed PMID: 16672163.
    PubMed

  • Evaluation of epitope tags for protein detection after in vivo CNS gene transfer.
    Shevtsova Z, Malik JM, Michel U, Schöll U, Bähr M, Kügler S.
    Eur J Neurosci. 2006 Apr;23(8):1961-9. PubMed PMID: 16630044.
    PubMed

  • Comparison of test systems for RNAinterference.
    Malik I, Garrido M, Bähr M, Kügler S, Michel U.
    Biochem Biophys Res Commun. 2006 Mar 3;341(1):245-53. Epub 2006 Jan 9. PubMed PMID: 16423323.
    PubMed

2005

  • Functional applications of novel Semliki Forest virus vectors are limited by vector toxicity in cultures of primary neurons in vitro and in the substantia nigra in vivo.
    Lingor P, Schöll U, Bähr M, Kügler S.
    Exp Brain Res. 2005 Mar;161(3):335-42. Epub 2004 Oct 20. PubMed PMID: 15502982.
    PubMed

  • Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.
    Lingor P, Koeberle P, Kügler S, Bähr M.
    Brain. 2005 Mar;128(Pt 3):550-8. Epub 2005 Jan 19. PubMed PMID: 15659426.
    PubMed

  • Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transfer.
    Malik JM, Shevtsova Z, Bähr M, Kügler S.
    Mol Ther. 2005 Mar;11(3):373-81. PubMed PMID: 15727933.
    PubMed

  • Long-term in vivo and in vitro AAV-2-mediated RNA interference in rat retinal ganglion cells and cultured primary neurons.
    Michel U, Malik I, Ebert S, Bähr M, Kügler S.
    Biochem Biophys Res Commun. 2005 Jan 14;326(2):307-12. PubMed PMID: 15582578.
    PubMed

  • Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo.
    Shevtsova Z, Malik JM, Michel U, Bähr M, Kügler S.
    Exp Physiol. 2005 Jan;90(1):53-9. Epub 2004 Nov 12. Review. PubMed PMID: 15542619.
    PubMed

2004

  • Increased protein expression from adenoviral shuttle plasmids and vectors by insertion of a small chimeric intron sequence.
    Hermening S, Kügler S, Bähr M, Isenmann S.
    J Virol Methods. 2004 Dec 1;122(1):73-7. PubMed PMID: 15488623.
    PubMed

  • Excess Bcl-XL increases the intrinsic growth potential of adult CNS neurons in vitro.
    Kretz A, Kügler S, Happold C, Bähr M, Isenmann S.
    Mol Cell Neurosci. 2004 May;26(1):63-74. PubMed PMID: 15121179.
    PubMed

  • Transfection of „naked“ siRNA results in endosomal uptake and metabolic impairment in cultured neurons.
    Lingor P, Michel U, Schöll U, Bähr M, Kügler S.
    Biochem Biophys Res Commun. 2004 Mar 19;315(4):1126-33. PubMed PMID: 14985130.
    PubMed

2003

  • Evidence for posttranscriptional regulation of the multi K homology domain protein vigilin by a small peptide encoded in the 5′ leader sequence.
    Rohwedel J, Kügler S, Engebrecht T, Purschke W, Müller PK, Kruse C.
    Cell Mol Life Sci. 2003 Aug;60(8):1705-15. PubMed PMID: 14504658.
    PubMed

  • Differential transgene expression in brain cells in vivo and in vitro from AAV-2 vectors with small transcriptional control units.
    Kügler S, Lingor P, Schöll U, Zolotukhin S, Bähr M.
    Virology. 2003 Jun 20;311(1):89-95. PubMed PMID: 12832206.
    PubMed

  • Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area.
    Kügler S, Kilic E, Bähr M.
    Gene Ther. 2003 Feb;10(4):337-47. PubMed PMID: 12595892.
    PubMed

2002

  • Adenovirus-mediated Bcl-X(L) expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice.
    Kilic E, Hermann DM, Kügler S, Kilic U, Holzmüller H, Schmeer C, Bähr M.
    Neurobiol Dis. 2002 Nov;11(2):275-84. PubMed PMID: 12505420.
    PubMed

  • Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis.
    Straten G, Schmeer C, Kretz A, Gerhardt E, Kügler S, Schulz JB, Gravel C, Bähr M, Isenmann S.
    Neurobiol Dis. 2002 Oct;11(1):123-33. PubMed PMID: 12460552.
    PubMed

  • Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo.
    Schmeer C, Straten G, Kügler S, Gravel C, Bähr M, Isenmann S.
    Eur J Neurosci. 2002 Feb;15(4):637-43. PubMed PMID: 11886444.
    PubMed

2001

  • Adenovirus-mediated glial cell line-derived neurotrophic factor (GDNF) expression protects against subsequent cortical cold injury in rats.
    Hermann DM, Kilic E, Kügler S, Isenmann S, Bähr M.
    Neurobiol Dis. 2001 Dec;8(6):964-73. PubMed PMID: 11741392.
    PubMed

  • Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand.
    Naumann U, Kügler S, Wolburg H, Wick W, Rascher G, Schulz JB, Conseiller E, Bähr M, Weller M.
    Cancer Res. 2001 Aug 1;61(15):5833-42. PubMed PMID: 11479223.
    PubMed

  • Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice.
    Hermann DM, Kilic E, Kügler S, Isenmann S, Bähr M.
    Neurobiol Dis. 2001 Aug;8(4):655-66. PubMed PMID: 11493030.
    PubMed

  • Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals.
    von Coelln R, Kügler S, Bähr M, Weller M, Dichgans J, Schulz JB.
    J Neurochem. 2001 Apr;77(1):263-73. PubMed PMID: 11279282.
    PubMed

  • Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis.
    Gerhardt E, Kügler S, Leist M, Beier C, Berliocchi L, Volbracht C, Weller M, Bähr M, Nicotera P, Schulz JB.
    Mol Cell Neurosci. 2001 Apr;17(4):717-31. PubMed PMID: 11312607.
    PubMed

  • Intravitreal adenoviral gene transfer evokes an immune response in the retina that is directed against the heterologous lacZ transgene product but does not limit transgene expression.
    Isenmann S, Engel S, Kügler S, Gravel C, Weller M, Bähr M.
    Brain Res. 2001 Feb 23;892(2):229-40. PubMed PMID: 11172769.
    PubMed

  • Neuron-specific expression of therapeutic proteins: evaluation of different cellular promoters in recombinant adenoviral vectors.
    Kügler S, Meyn L, Holzmüller H, Gerhardt E, Isenmann S, Schulz JB, Bähr M.
    Mol Cell Neurosci. 2001 Jan;17(1):78-96. PubMed PMID: 11161471.
    PubMed

2000

  • Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease.
    Eberhardt O, Coelln RV, Kugler S, Lindenau J, Rathke-Hartlieb S, Gerhardt E, Haid S, Isenmann S, Gravel C, Srinivasan A, Bahr M, Weller M, Dichgans J, Schulz JB.
    J Neurosci. 2000 Dec 15;20(24):9126-34. PubMed PMID: 11124990.
    PubMed

  • The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo.
    Kügler S, Straten G, Kreppel F, Isenmann S, Liston P, Bähr M.
    Cell Death Differ. 2000 Sep;7(9):815-24. PubMed PMID: 11042676.
    PubMed

  • Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo.
    Weise J, Isenmann S, Klöcker N, Kügler S, Hirsch S, Gravel C, Bähr M.
    Neurobiol Dis. 2000 Jun;7(3):212-23. PubMed PMID: 10860786.
    PubMed

1999

  • Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.
    Roth W, Isenmann S, Naumann U, Kügler S, Bähr M, Dichgans J, Ashkenazi A, Weller M.
    Biochem Biophys Res Commun. 1999 Nov 19;265(2):479-83. PubMed PMID: 10558893.
    PubMed

  • Transduction of axotomized retinal ganglion cells by adenoviral vector administration at the optic nerve stump: an in vivo model system for the inhibition of neuronal apoptotic cell death.
    Kügler S, Klöcker N, Kermer P, Isenmann S, Bähr M.
    Gene Ther. 1999 Oct;6(10):1759-67. PubMed PMID: 10516726.
    PubMed

  • Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma.
    Wagenknecht B, Glaser T, Naumann U, Kügler S, Isenmann S, Bähr M, Korneluk R, Liston P, Weller M.
    Cell Death Differ. 1999 Apr;6(4):370-6. PubMed PMID: 10381630.
    PubMed

1998

  • Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
    Brinckmann J, Açil Y, Feshchenko S, Katzer E, Brenner R, Kulozik A, Kügler S.
    Arch Dermatol Res. 1998 Apr;290(4):181-6. PubMed PMID: 9617436.
    PubMed

  • Identification of a new heterozygous point mutation in the COL1A2 gene leading to skipping of exon 9 in a patient with joint laxity, hyperextensibility of skin and blue sclerae. Mutations in brief no. 166. Online.
    Feshchenko S, Brinckmann J, Lehmann HW, Koch HG, Müller PK, Kügler S.
    Hum Mutat. 1998;12(2):138. PubMed PMID: 10694924.
    PubMed

1997

  • Chicken vigilin gene: a distinctive pattern of hypersensitive sites is characteristic for its transcriptional activity.
    Grünweller A, Purschke WG, Kügler S, Kruse C, Müller PK.
    Biochem J. 1997 Sep 1;326 ( Pt 2):601-7. PubMed PMID: 9291138; PubMed Central PMCID: PMC1218711.
    PubMed

1996

  • Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin.
    Kruse C, Grünweller A, Notbohm H, Kügler S, Purschke WG, Müller PK.
    Biochem J. 1996 Nov 15;320 ( Pt 1):247-52. PubMed PMID: 8947494; PubMed Central PMCID: PMC1217924.
    PubMed

  • Two additional 5′ exons in the human Vigilin gene distinguish it from the chicken gene and provide the structural basis for differential routes of gene expression.
    Kügler S, Plenz G, Müller PK.
    Eur J Biochem. 1996 Jun 1;238(2):410-7. PubMed PMID: 8681952.
    PubMed

  • Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus.
    Kügler S, Grünweller A, Probst C, Klinger M, Müller PK, Kruse C.
    FEBS Lett. 1996 Mar 18;382(3):330-4. PubMed PMID: 8605996.
    PubMed

1994

  • The human vigilin gene: identification, chromosomal localization and expression pattern.
    Plenz G, Kügler S, Schnittger S, Rieder H, Fonatsch C, Müller PK.
    Hum Genet. 1994 May;93(5):575-82. PubMed PMID: 8168838.
    PubMed